Twiner, M.J., Doucette, G.J., Rasky, A., Huang, X.-P., Roth, B.L., and Sanguinetti, M.C. (2012). The marine algal toxin azaspiracid is an open state blocker of hERG potassium channels. Chemical Research in Toxicology, 25, 1975-1984. PDF

Twiner, M.J., Hanagriff, J.C., Butler, S., Madhkoor, A.K., Doucette, G.J. (2012). Induction of apoptosis pathways in several cell lines following exposure to the marine algal toxin azaspiracid-1. Chemical Research in Toxicology, 25, 1493-1501. PDF

Twiner, M.J., Flewelling, L.J., Fire, S.E., Bowen-Stevens, S.R., Gaydos, J.K., Johnson, C.K., Landsberg, J.H., Leighfield,
T.A., Mase –Guthrie, B., Schwacke, L., Van Dolah, F.M., Wang, Z., Rowles, T.K. (2012). Comparative analysis of three brevetoxin-associated bottlenose dolphin (Tursiops truncatus) mortality events in the Florida Panhandle region (USA). PLoS One, 7, e42974. PDF

Twiner, M.J., El-Ladki, R.*, Kilcoyne, J., Doucette, G.J. (2012). Comparative effects of the marine algal toxins azaspiracid- 1, -2, and -3 on Jurkat T lymphocyte cells. Chemical Research in Toxicology, 25: 747-754. PDF

Butler, S.C.*, Miles, C.O., Karim, A.*, and Twiner, M.J. (2012). Inhibitory effects of pectenotoxins from marine algae on the polymerization of various actin isoforms. Toxicology In Vitro, 26, 493-499. PDF

Pang, Y., Fang, C., Twiner, M.J., Miles, C.O., Forsyth, C.J. (2011). Total synthesis and PPase inhibition of dinophysistoxin-2 and 2-epi-dinophysistoxin-2. Angew. Chem. Int. Ed., 50, 7631-7635. PDF

Rogers, E.D., Henry, T.B., Twiner, M.J., Gouffon, J.S., McPherson, J.T., Boyer, G.L., Sayler, G.S., and Wilhelm, S.W. (2011). Global gene expression profiling in larval zebrafish exposed to microcystin-LR and Microcystis reveals endocrine disrupting effects of cyanobacteria. Environmental Science and Technology, 45, 1962-1969. PDF

Twiner, M.J., Fire, S., Schwacke, L.H., Davidson, L., Wang, Z., Morton, S., Roth, S., Balmer, B.C., Rowles, T.K., Wells, R.S. (2011). Concurrent exposure of bottlenose dolphins (Tursiops truncatus) to multiple algal toxins in Sarasota Bay, Florida, USA. PLoS One 6(3): e17394. doi:10.1371/journal.pone.0017394. PDF

Schwacke, L.H., Twiner, M.J., De Guise, S., Balmer, B.C., Wells, R.S., Townsend, F.I., Rotstein, D.C., Varela, R.A., Hansen, L.J., Zolman, E.S., Spradlin, T.R., Levin, M., Leibrecht, H., Wang, Z., Rowles, T.K. (2010). Eosinophilia and biotoxin exposure in bottlenose dolphins (Tursiops truncatus) from a coastal area impacted by repeated mortality events. Environmental Research 110, 548-555. PDF

Twiner, M.J., Rehmann, N., Hess, P., Doucette, G.J. (2008). Azaspiracid Shellfish Poisoning: A review on the ecology, chemistry, toxicology and human health impacts. Marine Drugs (Special issue on Marine Toxins) 6, 39-72. PDF

Twiner, M.J., Ryan, J.C., Morey, J.S., Smith, K.J., Hammad, S.M., Van Dolah, F.M., Hess, P., McMahon, T., Satake, M., Yasumoto, T., and Doucette, G.J. (2008). Transcriptional profiling and inhibition of cholesterol biosynthesis in human lymphocyte T cells by the marine toxin azaspiracid. Genomics 91, 289-300. PDF

Fire, S.E., Flewelling, L.J., Naar, J., Twiner, M.J., Henry, M.S., Pierce, R.H., Gannon, D.P., Wang, Z., Davidson, L., and Wells, R.S. (2008). Prevalence of brevetoxins in prey fish of bottlenose dolphins in Sarasota Bay, Florida. Marine Ecology Progress Series 368, 283-294. PDF

Roth, P.B., Twiner, M.J., Mikulski, C.M., Barnhorst, A.B., and Doucette, G.J. (2008). Comparative analysis of the effects of two algicidal bacteria on the toxic dinoflagellate Karenia brevis. Harmful Algae 7, 682-691. PDF

Wiley, F.E., Twiner, M.J., Leighfield, T.A., Wilde, S.B., Van Dolah, F.M., Fischer, J.R., Bowerman, W.W. (2008). An extract of Hydrilla verticillata and associated epiphytes induces avian vacuolar myelinopathy in laboratory mallards. Environmental Toxicology 24, 362-368. PDF

Roth, P.B., Twiner, M.J., Wang, Z., Bottein Dechraoui, M-.Y., and Doucette, G.J. (2007). Fate and distribution of brevetoxin (PbTx) following lysis of Karenia brevis by algicidal bacteria, including analysis of open A-ring derivatives. Toxicon 50, 1175-1191. PDF

Twiner, M.J., Bottein-Dechraoui, M.-Y., Wang, Z., Mikulski, C.M., Henry, M.S., Pierce, R.H., Doucette, G.J. (2007). Extraction and analysis of lipophilic brevetoxins (PbTx) from the red tide dinoflagellate Karenia brevis. Analytical Biochemistry 369, 128-135. PDF

Hess, P., McCarron, P., Rehmann, N., Kilcoyne, J., McMahon, T., Ryan, G., Ryan, M.P., Twiner, M.J., Doucette, G.J., Satake, M., Ito, E., Yasumoto, T. (2007). Isolation and purification of AZAs from naturally contaminated materials, and evaluation of their toxicological effects (ASTOX). Marine Environment & Health Series, No. 28. Irish Marine Institute, Ireland. PDF

Hess, P, Rehmann, N., McCarron, P., Ryan, G., Ryan, M.P., Ito, E., Satake, M., Doucette, G., Twiner, M.J., Yasumoto, T., Aasen, J., Aune, T., Larsen, S. (2006). 2005 Progress report on ASTOX – research on azaspiracid standards and toxicology. 6th Irish Marine Biotoxin Science Workshop Proceedings. PDF

Kulagina, N.V., Twiner, M.J., Doucette, G.J., Ramsdell, J.S., Hess, P., McMahon, T., O'Shaughnessy, T.J., Ma, W. (2006). Effect of azaspiracid-1 on action potential generation and voltage-gated currents in cultured spinal cord neuronal networks. Toxicon 47, 766-773. PDF

Twiner, M.J., Hess, P., Bottein Dechraoui, M.-Y., McMahon, T., Ramsdell, J.S., Samons, M.S., Satake, M., Yasumoto, T., and Doucette, G.J. (2005). Cytotoxic and cytoskeletal effects of azaspiracid-1 on multiple mammalian cell lines. Toxicon 45, 891-900. PDF

Colman, J.R., Twiner, M.J., Hess, P., McMahon, T., Doucette, G.J. and Ramsdell, J.S. (2005). Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka Oryzias latipes embryos. Toxicon, 45, 881-890. PDF

Twiner, M.J., Chidiac, P., Dixon, S.J., and Trick, C.G. (2005). Extracellular organic compounds from the ichthyotoxic alga Heterosigma akashiwo elevate cytosolic calcium and induce apoptosis in Sf9 cells. Harmful Algae 4, 789-800. PDF

Twiner, M.J., Dixon, S.J. and Trick, C.G. (2004). Extracellular organics from specific cultures of Heterosigma akashiwo (Raphidophyceae) irreversibly alter respiratory activity in mammalian cells. Harmful Algae 3, 173-182. PDF

Twiner, M.J., Dixon, S.J. and Trick, C.G. (2001). Toxic effects of Heterosigma akashiwo do not appear to be mediated by hydrogen peroxide. Limnology and Oceanography 46, 1400-1405. PDF

Twiner, M.J., and Trick, C.G. (2000). Possible physiological mechanisms for production of hydrogen peroxide by the ichthyotoxic flagellate Heterosigma akashiwo. Journal of Plankton Research 22, 1961-1975. PDF

Twiner, M.J., Hirst, M., Valenciano, A., Zacharewski, T.E., and Dixon, S.J. (1998). N,N-Dimethylformamide modulates acid extrusion from murine hepatoma cells. Toxicology and Applied Pharmacology 153, 143-151. PDF